Table 3.

Mean ( ± SD) concentrations of biochemical parameters and multivariable-adjusted associations between biochemical parameters and PAPP-A2 concentration (pg/mL).

	Mean	±SD	All (n = 387)a		Men (n = 157)b		Women (n = 230)b		p for difference
			Diff in PAPP-A2 conc. (pg/mL)	p-value	Diff in PAPP-A2 conc. (pg/mL)	p-value	Diff in PAPP-A2 conc. (pg/mL)	p-value
Per SD difference
Creatinine	71.42	15.80 µmol/L	3.0	0.66	7.1	0.41	−4.6	0.69	0.35
Uric acid	294.14	84.35 µmol/L	0.5	0.95	−7.0	0.52	8.8	0.42	0.52
Triglycerides	1.69	1.12 mmol/L	−1.4	0.82	2.6	0.72	−10.3	0.35	0.23
HDL-C	1.57	0.50 mmol/L	1.2	0.86	8.0	0.53	−2.1	0.78	0.81
LDL-C	3.37	1.00 mmol/L	−4.4	0.49	0.0	0.99	−6.7	0.45	0.57
Cholesterol	5.37	1.15 mmol/L	−4.8	0.44	2.4	0.80	−9.8	0.26	0.38
HbA1c	5.62	0.45%	1.9	0.76	−1.4	0.87	4.8	0.59	0.89
Potassium	4.17	0.28 mmol/L	−1.4	0.81	5.4	0.56	−5.1	0.50	0.39
Sodium	139.46	1.96 mmol/L	8.1	0.15	4.6	0.62	10.4	0.15	0.70
GGT	0.46	0.45 µkat/L	13.6	0.02	16.3	0.04	10.0	0.28	0.52
ASAT	0.39	0.14 µkat/L	18.5	0.002	20.6	0.01	14.9	0.15	0.75
ALAT	0.41	0.25 µkat/L	11.4	0.07	13.6	0.08	4.1	0.74	0.46
LDH	2.67	0.54 µkat/L	14.9	0.02	20.8	0.02	9.4	0.32	0.27
Haemoglobin	8.34	0.72 mmol/L	−19.2	0.01	−4.7	0.70	−33.6	0.002	0.05
Haematocrit	0.40	0.03	−17.6	0.01	−5.1	0.63	−30.5	0.002	0.07
Red blood cells	4.47	0.38 Tpt/L	−21.5	0.001	−9.7	0.33	−36.4	0.0002	0.04
White blood cells	6.49	1.78 Gpt/L	−7.5	0.18	−15.2	0.09	−2.0	0.78	0.33

PAPP-A2, pregnancy-associated plasma protein-A2; diff., difference; conc., concentration; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; HbA_1c, glycated haemoglobin A1; GGT, γ-glutamyl transferase; ASAT, aspartate transaminase; ALAT, alanine aminotransferase; LDH, lactate dehydrogenase.

^aSeparate linear regression models for each biochemical parameter adjusted for age (continuously), sex, weight and pretest. ^bSeparate linear regression models for each biochemical parameter adjusted for age (continuously), weight and pretest.