Table 5.

Multivariable-adjusted associations between anthropometric and biochemical parameters and PAPP-A2 concentration (pg/mL) in participants without osteoporosis, diabetes, autoimmune diseases, inflammatory bowel diseases, or impaired kidney function (n = 330)^a.

	All (n = 330)		Men (n = 136)		Women (n = 194)		p for difference
	Diff. in PAPP-A2 conc. (pg/mL)	p-value	Diff. in PAPP-A2 conc. (pg/mL)	p-value	Diff. in PAPP-A2 conc. (pg/mL)	p-value
Per unit difference in
BMI (kg/m2)	−2.8	0.04	−1.8	0.43	−3.4	0.05	0.50
Weight (kg)	−1.0	0.02	−0.5	0.42	−1.4	0.02	0.26
Height (cm)	−0.9	0.29	−0.2	0.89	−1.4	0.21	0.53
Hip circumference (cm)	−0.9	0.18	−0.3	0.82	−1.1	0.17	0.54
Waist circumference (cm)	−1.0	0.06	−0.1	0.93	−1.7	0.02	0.15
Per SD difference in
Creatinine	−6.7	0.39	0.9	0.94	−13.8	0.22	0.30
Uric acid	−3.7	0.65	−5.8	0.64	−0.1	0.99	0.98
Triglycerides	−0.6	0.93	2.6	0.74	−8.7	0.46	0.26
HDL-C	2.7	0.69	13.7	0.33	−2.2	0.78	0.59
LDL-C	−1.0	0.89	2.3	0.82	−3.6	0.72	0.53
Cholesterol	−0.9	0.90	4.6	0.64	−6.3	0.52	0.39
HbA1c	−0.8	0.91	−3.4	0.73	1.6	0.87	0.93
Potassium	3.9	0.53	12.0	0.24	−0.1	0.99	0.35
Sodium	8.4	0.16	1.7	0.86	13.4	0.09	0.37
GGT	10.5	0.09	21.0	0.02	−2.1	0.82	0.05
ASAT	19.0	0.003	25.7	0.004	8.9	0.36	0.22
ALAT	10.9	0.11	16.8	0.06	−4.1	0.73	0.12
LDH	16.7	0.01	23.1	0.02	9.3	0.35	0.21
Haemoglobin	−19.5	0.02	−1.2	0.93	−36.1	0.001	0.03
Haematocrit	−19.4	0.01	−2.0	0.88	−35.3	0.0006	0.03
Red blood cells	−20.0	0.006	−8.7	0.42	−35.6	0.0009	0.05
White blood cells	−12.0	0.04	−18.1	0.06	−7.1	0.36	0.44

PAPP-A2, pregnancy-associated plasma protein-A2; diff., difference; conc., concentration.

^aSeparate linear regression models for each anthropometric or biochemical parameter adjusted for age (continuously), pretest and where appropriate for sex and weight (continuous).