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. 2017 Sep 5;7:10490. doi: 10.1038/s41598-017-09981-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IFNβ products display a differential pattern of impurity related innate immune response gene expression. (a) RAW-Blue cells were treated with indicated concentration Betaseron, Extavia, Avonex and Rebif for 24 h. The level of NF-κB activation in the supernatant was measured using QUATI-Blue as described in materials and methods. Each point represents mean ± SD pooled from 2 independent experiments. (b) Three different lots of Betaseron and Rebif were tested on RAW-Blue cells as above (c–h) Transcript levels of nos2, ptgs, ccl5, csf3, Il-1b and Il-1a in RAW-Blue cells Fold expression is calculated over media treated cells, data shows mean ± SD derived from the 2–3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.