Table 3.

Inhibitory effect of compounds 1 and 3 against TNF-α-induced NF-κB and lipopolysaccharide-stimulated iNOS activity.

Compound	NF-κB inhibition IC50 (μM)	NF-κB cytotoxicity IC50 (μM)	iNOS inhibition IC50 (μM)	iNOS cytotoxicity IC50 (μM)
1	7.1	>50	47.9 ± 0.03	>50
2	—	>50	43.2 ± 0.7	>50
3	1.5	>50	16.1 ± 6.6	>50
TPCKa	4.09 ± 0.12
l-NMMAb			18.8 ± 3.4

^aTPCK: N _α-tosyl-l-phenylalanine chloromethyl ketone was used as a positive control in NF-κB assay.

^bl-MNNA: Na-l- monomethyl arginine was used as a positive control in iNOS assay.