Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 5;7:10522. doi: 10.1038/s41598-017-11274-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Predicted model of TRPV4 channel interaction with 5′,6′-EET. (a) TRPV4 structural model showing only two of the four identical subunits (side view). Color-coded transmembrane segments S1-S4, TRP box and EET molecule are highlighted. Images of the predicted EET-binding site in TRPV4-WT (b,c) and TRPV4 K535A (d,e) systems. Residues showing more than 60% of time occupancy are displayed in licorice representation. K535A residue from TRPV4 K535A is displayed in licorice representation even though its interaction is not significant. (f,g) Bottom view detail of the interaction of 5′,6′-EET with residues K535 and R594 in the TRPV4-WT (f) and TRPV4-K535A (g) systems. Note the loss of interaction between mutated residue A535 and both D743 and EET molecule.