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. 2017 Sep 5;7:10522. doi: 10.1038/s41598-017-11274-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mutation K535A does not alter membrane localization of heterologously expressed TRPV4 channels. Co-localization of TRPV4-WT (a) and TRPV4-K535A (b) channels (green) expressed in HeLa cells with the plasma membrane marker concanavalin A (magenta). Co-localized pixels are shown in white in the merge panels. The yellow line on the merge panels indicates the plot profile analysis (c) performed on each image using ImageJ software. Scale bar = 20 μm. (d) Pearson correlation coefficients obtained with the plot profile analysis of TRPV4-WT and TRPV4-K535A channels in the plasma membrane location. Mean ± S.E.M., P = 0.1 Mann-Whitney.