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. 2017 Sep 5;7:10435. doi: 10.1038/s41598-017-10756-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sequence diagram of the rs2071166 site and the Cx43 mRNA level in patients with different genotypes. (a) Arrows indicate the SNP site. Genotype: top, AA; middle, AC; bottom, CC. Green, black, red and blue represent the A allele, G allele, T allele and C allele, respectively. (b) The Cx43 promoter region is similar among mammals, such as chimpanzee, gorilla and mouse lemur, etc. The position of the SNP site was marked by black arrows. (c,d) The relative mRNA expression level of Cx43 was analyzed in samples from 9 patients with the AA/AC genotype and 8 patients with the CC genotype, with B2M as an internal control. Bar, SE. *p < 0.05.