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. 2017 Sep 5;7:10435. doi: 10.1038/s41598-017-10756-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The C allele alters the binding between RXRα and the Cx43 RARE. HeLa whole-cell extracts were treated with DMSO or RA and then incubated with biotin-labeled A allele-specific, C allele-specific and competitor probes in an EMSA. The arrows indicate the free probe and the specific DNA-protein complex shift. Lane 1: A allele-specific probe only; Lanes 2 and 3: A allele-specific probe + protein; Lanes 4 and 5: competitor C allele-specific probe + protein; Lane 6: C allele-specific probe only; Lanes 7 and 8: C allele-specific probe + protein; Lanes 9 and 10: competitor C allele-specific probe + protein.