Table 1.

Von Willebrand disease (VWD) classification according to the International Society on Thrombosis and Hemostasis [9]

Type of VWD	Description	% of total VWD population (%)
1	Partial quantitative deficiency of VWF	70–80
2	Qualitative VWF defects	~20
2A	Decreased VWF-dependent platelet adhesion and a deficiency of high-molecular-weight VWF multimers
2B	Increased affinity for platelet glycoprotein Ib (GpIb) and a deficiency of high-molecular-weight VWF multimers
2M	Decreased VWF-dependent platelet adhesion without a deficiency of high-molecular weight VWF multimers
2N	Markedly decreased binding affinity for FVIII
3	Virtually complete deficiency of VWF	<5

VWF von Willebrand factor