Table 1.

FLIM-FRET parameters predictors of doxorubicin drug response in PCa cell lines.

FLIM parameters/Molecular Targets	Molecular Changes in LNCaP & E006AA Doxorubicin Rx in “Pre-Apoptotic” Phase (0–60 min)	Molecular changes in LNCaPs Cells Doxorubicin “Responsive” (~24 hr)	Molecular changes in E006AA Cells Doxorubicin “Slow Responders” (~24 hr)
NAD(P)H-τm	Increases	Increases	Increases
NAD(P)H-a2%	Increases	Increases	Increases
FAD-a1%	Decreases	Decreases	Decreases
NAD(P)H-a2%/FAD-a1% FLIM Redox Ratio	Increases	Increases	Increases
E% vs NAD(P)H-a2%/FAD-a1% Correlation	Increases	Decreases	No Change