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. 2017 Sep 5;8:441. doi: 10.1038/s41467-017-00524-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The boundaries of GRBs are highly consistent regardless of the thresholds or species involved. a The human MEIS1 locus is spanned by arrays of conserved noncoding elements (CNEs) identified in comparisons with opossum, chicken and spotted gar. These CNEs can be visualised as a smoothed density, shown here as a horizon plot. The boundaries of the proposed GRBs at the MEIS1 locus are highly consistent regardless of the species or thresholds involved. b All hg19-galGal4 GRBs centred and ordered by length of the GRB. c Distribution of CNEs in a window of 8 Mb around the centre of the hg19-galGal4 GRBs for different sets of CNEs. d Overlap of putative GRBs obtained using comparisons between hg19-monDom5 and hg19-lepOcu1 with these sets of GRBs identified using CNEs using hg19-galGal4 (70%/50 bp)