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. 2017 Sep 5;8:441. doi: 10.1038/s41467-017-00524-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The boundaries of GRBs predict the boundaries of TADs in multiple evolutionarily distant species. a Heatmaps representing H1-ESC directionality index spanning an 8 Mb window around the centre of putative hg19-galGal4 GRBs. Showing both the overall direction (middle panel, red for downstream, blue for upstream) and the average raw directionality score in 5 kb bins (right panel). b Heatmaps of Drosophila embryo Hi-C directionality index spanning a 2 Mb window around the centre of dm3-droMoj3 GRBs. Showing both the overall direction (middle panel, red for downstream, blue for upstream) and the average raw directionality score in 1 kb bins (right panel). c A large number of GRBs were found to be located within individual TADs (identified using HOMER) or overlapping only a single TAD, regardless of cell lineage (H1-ESC (H1), mesenchymal stem cells (MS), mesendoderm (ME), neural progenitor cells (NP) and trophoblast-like (TB)). d Cumulative distribution of distance to nearest TAD (HOMER) boundaries from GRB boundaries in different cell lineages considering both edges, i.e., both the start and end positions of a GRB lie within X kb of the nearest TAD start and end