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. 2017 Sep 5;8:441. doi: 10.1038/s41467-017-00524-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Examples of genomic regulatory blocks and their associated interaction landscapes in human. GRBs at several human loci show strong association with the structure of regulatory domains proposed from Hi-C. a The GRB containing MEIS1 (chr2:65270920-68723490) accurately predicts the span of regulatory interactions defined by Hi-C. b The region located at chr6-44198640-46071520 contains both the transcription factor RUNX2 and its bystander gene SUP3TH (shown in brown), both of which are located within a GRB which predicts the topological organisation of the locus. c A region located on chr16:48476700-55776880 in hg19 contains several GRBs containing important developmental regulators, including IRX3/5/6, TOX3, SALL1, NKD1 and ZNF423, which exhibit strong concordance with TADs. The IRX3/5/6 locus contains homeobox proteins which have multiple functions during animal development and contains a well-known bystander gene FTO (shown in brown), which contains an intronic enhancer which drives expression of IRX3 ^38–41