Fig. 5.

The span of CNEs in various species is predictive of genome size and TAD size. a Distribution of genome size, TAD size and GRB size in opossum, humans, mouse, chicken, spotted gar and Drosophila. b Sizes of 17 stringent GRBs identified in various species shows direct expansion and growth in line with that expected given differences in genome size. c Correlation of sizes of GRBs identified in one species compared to other species and to the corresponding TADs in humans finds that the size of a GRB identified in other species is highly predictive of the size and scope of regulatory domains in other species