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. 2017 Sep 5;7:10530. doi: 10.1038/s41598-017-10444-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Measures of skin temperature at the last five minutes of the second warm period as estimated with the equations used in the respective references. (A) Mean skin temperature: *P ≤ 0.001: 14-ISO vs. Boon; ^†P ≤ 0.001: 8-ISO vs. Boon; ^#P = 0.002: 4-ISO vs. Boon; ^‡P = 0.001: Boon vs. PROFITH. (B) Proximal skin temperature: All P = 1.000. (C) Distal skin temperature: P = 0.113. (D) Body temperature gradients: P = 0.252. (E) Supraclavicular temperature gradients: All P ≥ 0.575. (F) Peripheral temperature gradient: All P = 1.000. Data are mean and standard error.