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. 2017 Sep 5;7:10559. doi: 10.1038/s41598-017-11216-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Two representative cases of brain Magnetic Resonance Imaging analysis. Top row: images from a subject with a high number/volume of white matter hyperintensities (WMH) are shown. Bottom row: scans of a subject with a low number/volume of WMH. In both cases, WMH are countered in red, by using semi-automated software. Arrows underlines some of the WMH.