Table 1.
Preoperative sCA125 and sHE4 levels in all 293 EC patients divided according to clinicopathological features
| Variables | n. | HE4 pmol/L | CA125 U/mL | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Median | Range | 95th perc | p-value | Median | Range | 95th perc | p-value | ||
| Age (years) | |||||||||
| <50 | 22 | 49.70 | 24,70–176 | 148.87 | 20.15 | 5,00–433,00 | 373.48 | ||
| ≥50 | 271 | 78.00 | 6,5–653 | 312.00 | 0.0247 | 17.25 | 2,40–2922,00 | 120.11 | 0.4134 |
| BMI | |||||||||
| <18.5 | 5 | 97.50 | 54,00–649,00 | 543.76 | 18.00 | 12,70–60,00 | 58.60 | ||
| 18.5–25 | 102 | 76.75 | 6,50–639,40 | 410.22 | 19.50 | 3,90–961,00 | 198.00 | ||
| 25–30 | 94 | 69.35 | 24,70–410,00 | 262.66 | 15.20 | 2,40–165,20 | 67.10 | ||
| ≥30 | 78 | 83.95 | 32,20–653,00 | 316.5 | 0.2106 | 17.95 | 3,30–2922,00 | 197.76 | 0.0927 |
| Missing values | 14 | ||||||||
| Number of children | |||||||||
| <4 | 275 | 76.60 | 6,50–653,00 | 279.53 | 17.25 | 2,40–2922,00 | 141.89 | ||
| ≥4 | 18 | 87.70 | 45,00–649,00 | 393.06 | 0.0476 | 18.95 | 3,7–107,50 | 61.17 | 0.8244 |
| Menopause status | |||||||||
| No | 35 | 52.20 | 24,70–541,90 | 165.92 | 16.80 | 5,00–433,00 | 282.30 | ||
| Yes | 257 | 79.40 | 6,50–653,00 | 312.00 | 0.0087 | 17.75 | 2,40–2922,00 | 120.05 | 0.6322 |
| Missing values | 1 | ||||||||
| Contraception | |||||||||
| No | 193 | 77.00 | 24,70–653,00 | 312.00 | 18.15 | 2,40–2922,00 | 155.74 | ||
| Yes | 13 | 60.20 | 32,20–176,00 | 159.86 | 0.0653 | 15.00 | 6,2–433,00 | 316.00 | 0.7334 |
| Missing values | 87 | ||||||||
| HRT | |||||||||
| No | 223 | 76.70 | 6,50–653,00 | 311.23 | 18.25 | 3,30–2922,00 | 172.61 | ||
| Yes | 41 | 64.20 | 19,40–410,00 | 175.00 | 0.0480 | 16.90 | 2,40–118,00 | 71.70 | 0.3554 |
| Missing values | 29 | ||||||||
| Hypertension | |||||||||
| No | 143 | 67.00 | 6,50–653,00 | 223.69 | 17.80 | 3,30–2922,00 | 162.54 | ||
| Yes | 150 | 85.90 | 30,80–639,40 | 312.00 | 0.0010 | 17.70 | 2,40–497,40 | 96.50 | 0.3873 |
| Grading from biopsy | |||||||||
| Hyperplasia | 6 | 46.90 | 30,80–53,30 | 52.77 | 10.65 | 7,90–15,40 | 14.50 | ||
| G1 | 82 | 67.65 | 24,70–526,00 | 219.18 | 17.25 | 5,20–263,00 | 77.76 | ||
| G2 | 91 | 85.90 | 19,40–649,00 | 311.50 | 20.60 | 3,30–497,40 | 120.11 | ||
| G3 | 87 | 78.00 | 6,50–653,00 | 308.61 | 0.0013 | 16.80 | 4,60–2922,00 | 186.20 | 0.0664 |
| Missing values | 27 | ||||||||
| Clinical stage (presurgical) | |||||||||
| Early (FIGO ≤I) | 246 | 72.95 | 6,50–639,40 | 294.10 | 17.00 | 2,40–263,00 | 73.14 | ||
| Advanced (FIGO > I) | 44 | 103.55 | 41,00–653,00 | 531.10 | <0.001 | 36.55 | 5,90–2922,00 | 487.74 | <0.001 |
| Missing values | 3 | ||||||||
| Surgical FIGO stage | |||||||||
| I | 194 | 66.10 | 6,50–346,70 | 197.40 | 15.90 | 2,40–238,00 | 58.12 | ||
| >I | 99 | 107.40 | 34,5–653,00 | 526.60 | <0.001 | 25.00 | 3,90–2922,00 | 299.90 | 0.0063 |
| Histotype | |||||||||
| Non endometrioid | 39 | 71.00 | 31,70–653,00 | 424.74 | 26.00 | 4,70–2922,00 | 220.07 | ||
| Endometrioid | 254 | 76.80 | 6,50–649,00 | 301.96 | 0.5963 | 17.20 | 2,40–961,00 | 106.60 | 0.0629 |
| Surgical Grading | |||||||||
| G1 | 68 | 61.95 | 24,70–304,30 | 152.70 | 15.90 | 2,40–238,00 | 51.16 | ||
| G2 | 127 | 84.50 | 6,50–649,00 | 321.69 | 18.10 | 3,30–497,40 | 120.14 | ||
| G3 | 98 | 84.25 | 31,70–653,00 | 415.22 | <0.001 | 19.00 | 3,90–2922,00 | 197.76 | 0.1543 |
| Myometrial invasion | |||||||||
| M0 | 37 | 48.90 | 6,50–138,90 | 103.12 | 15.20 | 4,70–71,20 | 42.25 | ||
| M1 | 107 | 66.20 | 31,70–653,00 | 215.68 | 15.50 | 2,40–2922,00 | 54.40 | ||
| M2 | 149 | 94.00 | 19,40–649,00 | 412.10 | <0.001 | 22.00 | 3,70–961,00 | 188.00 | <0.001 |
| Extension to cervix | |||||||||
| No | 208 | 67.60 | 6,50–653,00 | 219.86 | 17.00 | 2,40–2922,00 | 95.20 | ||
| Yes | 85 | 94.70 | 34,50–649,00 | 412.80 | <0.001 | 20.50 | 4,60–961,00 | 190.76 | 0.0104 |
| Ovarian metastases | |||||||||
| No | 260 | 72.95 | 6,50–649,00 | 226.61 | 16.90 | 2,40–389,00 | 84.69 | ||
| Yes | 31 | 100.30 | 50,50–653,00 | 536.95 | <0.001 | 40.00 | 7,00–2922,00 | 729.20 | <0.001 |
| Missing values | 2 | ||||||||
| Lymph nodes status | |||||||||
| Negative | 243 | 70.70 | 6,50–649,00 | 223.19 | 15.90 | 2,40–238,00 | 59.91 | ||
| Positive | 40 | 108.40 | 50,50–532,00 | 410.75 | <0.001 | 38.25 | 4,60–961,00 | 394.42 | <0.001 |
| Missing values | 10 | ||||||||
| Lymphovascular invasion | |||||||||
| Absent | 128 | 62.10 | 6,50–347,90 | 159.37 | 14.30 | 2,40–238,00 | 57.01 | ||
| Present | 156 | 90.05 | 19,40–653,00 | 416.38 | <0.001 | 22.90 | 3,90–2922,00 | 201.57 | <0.001 |
| Missing values | 9 | ||||||||
| Positive peritoneal cytology | |||||||||
| No | 258 | 74.65 | 6,50–649,00 | 275.30 | 17.00 | 2,40–497,40 | 109.60 | ||
| Yes | 29 | 110.00 | 50,50–653,00 | 537.94 | <0.001 | 32.00 | 7,00–2922,00 | 692.60 | <0.001 |
| Missing values | 6 | ||||||||
p-values were computed using non-parametric Wilcoxon-Mann-Whitney or Kruskal-Wallis test. In bold p-values < 0.05. Missing values are not considered in the test procedure.
BMI = Body Mass Index; HRT = Hormone Replacement Therapy.