Table 5.
Characteristics of the different study cohorts used in the study.
| Cohort | Type | Genotype* tested | MAF | Phenotype data available | Total no. of participants | Ref. | Remarks |
|---|---|---|---|---|---|---|---|
| Inter 99 | Population-based | rs12979860 (g) | 0.34 | Atopy Asthma | 5341 | 19 | Atopy determined by serum specific IgE; self-reported doctor-diagnosed asthma |
| Health 2006 | Population-based | rs12979860 (g) | 0.34 | Atopy Asthma | 3134 | 20 | |
| COPSAC | Case-control (hospital-based; parents of asthmatic children) | rs12979860 (g) | 0.30 | Atopy Asthma | 551 | 21 | All participants below 50 yr of age; Atopy determined by serum specific IgE |
| GERA | Population-based | rs12979860 (i); rs8099917 (i) | 0.32; 0.19 | Allergic rhinitis, Asthma | 56637 | 18 | Average age 63 yr (range18 to over 100 yr) |
| Polish | Hospital-based Case-control | rs368234815 (g) | 0.34 | Atopy, asthma | 437 | — | Atopy determined by SPT; asthma treated and monitored |
*g-genotyped; i-imputed; MAF-minor allele frequency.