Table 8.
Association of the functional IFN-λ4-generating polymorphism rs368234815 with clinical features of asthma in women > 50 yr age sub-group in the Polish cohort.
| BDR | iCS | oCS | |
|---|---|---|---|
| TT/ΔG + ΔG/ΔG (n/N, %) | 41/64, 64.1 | 61/83, 73.5 | 2/83, 2.4 |
| TT/TT (n/N, %) | 20/49, 40.8 | 54/61, 88.5 | 8/61, 13.1 |
| OR crude | 2.583 | 0.359 | 0.163 |
| 95% CI | 1.203–5.55 | 0.142–0.907 | 0.033–0.8 |
| p | 0.01 | 0.03 | 0.02 |
| OR adjusted* | 4.651 | 0.112 | 0.146 |
| 95% CI | 1.414–15.15 | 0.02–0.619 | 0.013–1.594 |
| p | 0.01 | 0.01 | 0.10 |
| OR adjusted** | 2.262 | 0.248 | 0.227 |
| 95% CI | 0.975–5.235 | 0.081–0.751 | 0.041–1.237 |
| p | 0.05 | 0.01 | 0.08 |
Dominant model of inheritance for the minor allele (TT/ΔG + ΔG/ΔG vs TT/TT) was tested; No significant results were seen under the recessive model. *OR adjusted for age, age at asthma diagnosis, FeNO, BMI, FEV1% and atopy; **OR adjusted for atopy. p < 0.05 was considered significant and is shown in bold.