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. 2017 Sep 5;7:10504. doi: 10.1038/s41598-017-10692-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fold-change in mRNA expression of P0 vs E12.5 NDCs and immunohistochemical analysis of key ECM molecules at E12.5 and P0. (A) Fold-change in mRNA expression of proteoglycans and collagens showing significant upregulation at P0. Protein staining for (B) COL1, (C) COL2, (D) COL6, and (E) ACAN, showing weak staining in non-cellular regions (core and sheath) of the E12.5 notochord and intense positive staining of the NP at P0. N = 4, all fold changes p < 0.05, P0 compared to E12.5, analyzed by DESeq2 and adjusted for false discovery rate. Refer to Fig. 2 for annotation of structural regions.