Table 1.
Fold-change in mRNA expression of Shh pathway genes at P0 compared to E12.5.
| Gene | Name | Fold Change in Expression P0 vs E12.5 | p value |
|---|---|---|---|
| Gli1 | GLI family zinc finger 1 | −7.99 | 1.05E-18 |
| Gli2 | GLI family zinc finger 2 | −9.23 | 1.00E-12 |
| Gli3 | GLI family zinc finger 3 | −5.27 | 5.35E-07 |
| GliS1 | GLIS family zinc finger 1 | −7.43 | 1.09E-07 |
| GliS2 | GLIS family zinc finger 2 | −3.13 | 2.31E-04 |
| Hhip | Hedgehog interacting protein | −9.86 | 6.54E-15 |
| Ptch1 | Patched 1 | −6.72 | 3.34E-17 |
| Ptch2 | Patched 2 | −5.05 | 1.36E-04 |
| Shh | Sonic Hedgehog | −87.82 | 8.84E-12 |
| Smo | Smoothened | −2.03 | 5.07E-03 |
| Sufu | SUFU negative regulator of hedgehog signaling | −2.05 | 1.89E-03 |
N = 4, Differential expression analyzed by DESeq2 and p values adjusted for false discovery rate.