Table 2.
Fold-change in mRNA expression of TGF-β pathway genes at P0 compared to E12.5.
| Gene | Name | Fold Change in Expression | p value |
|---|---|---|---|
| P0 vs E12.5 | |||
| Acvr2a | activin A receptor type IIA | 4.39 | 1.71E-04 |
| Acvr2b | activin A receptor type IIB | −7.92 | 3.35E-16 |
| Bmp1 | Bone morphogenetic protein 1 | −2.04 | 1.28E-02 |
| Bmp2k | BMP2-inducible protein kinase | 2.66 | 7.52E-03 |
| Bmp3 | Bone morphogenetic protein 3 | −5.93 | 2.35E-08 |
| Bmp4 | Bone morphogenetic protein 4 | −3.13 | 1.98E-05 |
| Bmp7 | Bone morphogenetic protein 7 | −4.45 | 3.10E-08 |
| Bmpr1b | Bone morphogenetic protein receptor type-1B | −4.05 | 9.93E-05 |
| Fst | Follistatin | −3.79 | 9.09E-07 |
| Grb2 | growth factor receptor bound protein 2 | 2.64 | 1.32E-04 |
| Grem1 | Gremlin 1 | 3.77 | 1.11E-03 |
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 3.49 | 2.63E-07 |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 3.28 | 8.34E-04 |
| Nog | noggin | −28.36 | 3.52E-19 |
| Smad5 | SMAD family member 5 | −2.24 | 4.29E-06 |
| Smad6 | SMAD family member 6 | −2.39 | 7.15E-03 |
| Smad7 | SMAD family member 7 | −1.89 | 3.37E-02 |
| Sostdc1 | sclerostin domain containing 1 | 9.09 | 1.83E-10 |
| Tfe3 | transcription factor binding to IGHM enhancer 3 | 2.04 | 5.43E-03 |
| Tgfb1 | Transforming growth factor beta 1 | 11.18 | 2.38E-11 |
| Tgfbr2 | Transforming growth factor beta receptor 2 | 3.92 | 2.86E-08 |
| Znf423 | zinc finger protein 423 | −9.70 | 3.89E-23 |
N = 4, Differential expression analyzed by DESeq2 and p values adjusted for false discovery rate.