Table 3.

Fold-change in mRNA expression of IGF pathway genes at P0 compared to E12.5.

Gene	Name	Fold Change in Expression P0 vs E12.5	p value
Elk1	ELK1, member of ETS oncogene family	−1.86	1.61E-02
Fos	FBJ murine osteosarcoma viral oncogene homolog	23.33	4.50E-12
Foxo1	forkhead box O1	1.82	3.55E-02
Grb10	growth factor receptor bound protein 10	−3.99	6.37E-07
Grb2	growth factor receptor bound protein 2	2.64	1.32E-04
Igf1	insulin-like growth factor 1	4.12	2.64E-03
Igf2	insulin-like growth factor 2	−10.88	1.45E-15
Igfbp2	insulin-like growth factor binding protein 2	−3.04	1.09E-02
Igfbp3	insulin-like growth factor binding protein 3	−5.06	7.78E-06
Igfbp5	insulin-like growth factor binding protein 5	−13.16	3.92E-23
Igfbp6	insulin-like growth factor binding protein 6	9.11	2.15E-04
Igfbp7	insulin-like growth factor binding protein 7	9.92	1.05E-09
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	−9.22	5.53E-29
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	−12.52	7.07E-31
Igf2bp3	insulin-like growth factor 2 mRNA binding protein 3	−1.87	2.46E-03
Igf2os	insulin-like growth factor 2, opposite strand	−10.24	2.11E-09
Igf2r	insulin-like growth factor 2 receptor	−3.18	3.43E-04
Irs1	insulin receptor substrate 1	−3.22	1.04E-03
Jak1	Janus kinase 1	2.77	3.88E-05
Jak2	Janus kinase 2	1.98	3.85E-03
Stat3	signal transducer and activator of transcription 3 (acute-phase response factor)	2.89	6.16E-06

N = 4, Differential expression analyzed by DESeq2 and p values adjusted for false discovery rate.