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. 2017 Sep 5;7:10540. doi: 10.1038/s41598-017-10076-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Energy state of the kidney following CypD ablation. (A) Comparison of ATP/ADP-ratios and energy charge between the kidneys of female and male Ppif−/− (KO) and wild-type (WT) mice. Data is presented as average ± SD (n = 9–14) (measured concentrations [µM] were normalized to protein [mg] prior to ratio calculations). (B) Expression of Glut1 glucose transporter. Data was normalized to β-actin and is presented as average ± SD (arbitrary units, n = 4). One-way ANOVA results with Tukey post-hoc significance levels are presented below. Abbreviations: ADP: adenosine diphosphate, ATP: adenosine triphosphate, AMP: adenosine monophosphate, energy charge calculated as [ATP + (0.5 × ADP)]/(ATP + ADP + AMP).