Figure 2.
PPI fingerprints of the proteins in the Duarte et al. dataset. 83 biological interfaces (bio) are shown in blue, 82 crystal contacts (xtal) in grey. We see how the conservation score (y-axis), computed on MSAs generated with different sequence identity inclusion thresholds (x-axis), is helping to discriminate between crystal contacts and biological relevant interfaces. Using an inclusive MSA (0–25% sequence identity thresholds) the two non-normal distributions overlap to a large extent (Mann-Whitney p-values between 8.12 × 10−7 and 3.82 × 10−8), while in the threshold range between 35–55% they are clearly separable (Mann-Whitney p-values between 7.47 × 10−11 and 4.56 × 10−13).