Table 5.
Pathology details
| Cisplatin and fluorouracil (n=387)* | Epirubicin, cisplatin, and capecitabine (n=364)* | |
|---|---|---|
| Type of tumour | ||
| Squamous | 5/386 (1%) | 1/360 (<1%) |
| Adenocarcinoma | 370/386 (96%) | 336/360 (93%) |
| Other | 11/386 (3%) | 23/360 (6%) |
| Differentiation | ||
| Well | 25/379 (7%) | 28/336 (8%) |
| Moderate | 167/379 (44%) | 158/336 (47%) |
| Poor | 187/379 (49%) | 150/336 (45%) |
| Mandard tumour regression grade (local pathology assessment) | ||
| 1: Complete regression | 9/288 (3%) | 32/289 (11%) |
| 2: Mainly fibrosis | 9/288 (3%) | 16/289 (6%) |
| 3: Increased residual cancer cells | 26/288 (7%) | 45/289 (16%) |
| 4: Residual cancer cells outgrowing fibrosis | 104/288 (9%) | 97/289 (34%) |
| 5: Absence of regressive changes | 140/288 (49%) | 99/289 (34%) |
| Mandard tumour regression grade (central pathology review) | ||
| 1: Complete regression | 5/339 (1%) | 21/317 (7%) |
| 2: Mainly fibrosis | 7/339 (2%) | 16/317 (5%) |
| 3: Increased residual cancer cells | 28/339 (8%) | 54/317 (17%) |
| 4: Residual cancer cells outgrowing fibrosis | 194/339 (57%) | 164/317 (52%) |
| 5: Absence of regressive changes | 105/339 (31%) | 62/317 (20%) |
| Complete resection at all margins | ||
| No | 143/379 (38%) | 108/357 (30%) |
| Yes | 236/379 (62%) | 249/357 (70%) |
| Staging ypT | ||
| 0 | 6/383 (2%) | 19/359 (5%) |
| 1 | 28/383 (7%) | 49/359 (14%) |
| 2 | 67/383 (17%) | 58/359 (16%) |
| 3 | 270/383 (70%) | 223/359 (62%) |
| 4 | 12/383 (3%) | 10/359 (3%) |
| Staging ypN | ||
| 0 | 115/385 (30%) | 142/361 (39%) |
| 1 | 232/385 (60%) | 191/361 (53%) |
| 2 | 28/385 (7%) | 19/361 (5%) |
| 3 | 10/385 (3%) | 9/361 (2%) |
| Staging ypM | ||
| 0 | 80/378 (21%) | 90/356 (25%) |
| 1 | 22/378 (6%) | 13/356 (4%) |
| X | 276/378 (73%) | 253/356 (71%) |
| Extent of resection | ||
| R0: absolute curative | 212/357 (59%) | 223/336 (66%) |
| R1: relative curative | 130/357 (36%) | 103/336 (31%) |
| R2: non-curative | 15/357 (4%) | 10/336 (3%) |
Data are n/N (%). Denominators are total specimens in which the parameter could be assessed and results were not missing. ypT=pathological T-stage. ypN=pathological N-stage. ypM=pathological M-stage. R0=no tumour cells within 1 mm of any resection margin. R1=presence of tumour cells at or within 1 mm of a longitudinal or radial or circumferential resection margin. R2=macroscopically visible tumour left behind during surgery.
*
Total number of patients for whom specimens were obtained.