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| Hepatocyte necrosis | 0.25 ± 0.2 | 2.3 ± 0.25∗∗ | 0.8 ± 0.3# |
| Fibrosis | 0.38 ± 0.18 | 2.1 ± 0.3∗ | 0.8 ± 0.1# |
| Cellular infiltration | 0.2 ± 0.1 | 1.38 ± 0.16∗ | 0.9 ± 0.35# |
∗∗ p < 0.0001, MTX + lactulose group compared with normal group. ∗p < 0.01, MTX + lactulose group compared with normal group. #p < 0.05, MTX + lactulose group compared with MTX + saline group.
