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General scheme of insulin signaling in adipocytes with the main metabolic effects. AS160: Akt substrate 160 kDa; GSK3: glycogen synthase kinase type 3; IRS: insulin receptor substrate; MAPK: mitogen-activated protein kinase; mTORC2: mechanistic target of rapamycin; PI-3K: phosphatidylinositol-3-kinase; PDK-1: phosphoinositide-dependent kinase; S6K: ribosomal protein S6 kinase. According to Boucher et al. [15], with changes.
