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. 2017 Aug 22;2017:1791403. doi: 10.1155/2017/1791403

Figure 3.

Figure 3

Histopathological features of the knee joint tissues of rats with MIA-induced OA. (a) Representative histological analysis (Safranin O staining) of the knee joint in MIA-induced OA. (b–d) The levels of gelatinase A (MMP-2), gelatinase B (MMP-9), and COX-2 in the femur joint were measured by ELISA. The levels of (e) DPD in urine and (f) osteocalcin in serum were measured by ELISA. # indicates p < 0.05 and ## indicates p < 0.01 when compared to saline group (NC). ∗ indicates p < 0.05, ∗∗ indicates p < 0.01, and ∗∗∗ indicates p < 0.001 when compared to the control group (CTL).