Table 2.
Comparison of aldose reductase, malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) in lens of all groups. C: control group; DM + vehicle: diabetic rats (DM) which received vehicle; DM + MPO (2 mg/kg·BW): diabetic rats (DM) which received MPO at doses of 2 mg/kg·BW; DM + MPO (10 mg/kg·BW): diabetic rats (DM) which received MPO at doses of 10 mg/kg·BW; DM + MPO (50 mg/kg·BW): diabetic rats (DM) which received MPO at doses of 50 mg/kg·BW (N = 10/group). #,##,###p value < .05, .01, and .001, respectively, compared with control group and ∗,∗∗,∗∗∗p value < .05, .01, and .001, respectively, compared with diabetic rats which received vehicle (DM + vehicle).
| Group | MDA (U/mg protein) | CAT (U/mg protein) | GPx (U/mg protein) | SOD (U/mg protein) | AR (nmol/min/mg) |
|---|---|---|---|---|---|
| Control | 0.52 ± 0.08 | 19.55 ± 0.59 | 1.01 ± 0.11 | 8.98 ± 0.34 | 0.005 ± 0.001 |
| DM + vehicle | 1.06 ± 0.10### | 13.04 ± 0.84### | 0.62 ± 0.04## | 6.83 ± 0.87# | 0.013 ± 0.004## |
| DM + MPO (2 mg/kg·BW) | 0.73 ± 0.03∗∗∗ | 17.91 ± 0.55∗∗ | 0.80 ± 0.10 | 8.06 ± 0.36 | 0.007 ± 0.001∗ |
| DM + MPO (10 mg/kg·BW) | 0.87 ± 0.05∗ | 17.69 ± 0.92∗∗ | 0.85 ± 0.01∗ | 7.28 ± 0.43 | 0.008 ± 0.001∗ |
| DM + MPO (50 mg/kg·BW) | 0.98 ± 0.05 | 16.61 ± 1.35∗ | 0.71 ± 0.04 | 6.10 ± 0.52 | 0.008 ± 0.001∗ |