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. 2017 Jul 28;14(4):2801–2808. doi: 10.3892/etm.2017.4846

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Copyright: © Leng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Characterization of two ALDH^high CSCs subpopulations. (A) mRNA levels of the stem cell related genes Oct4, Sox2, Nanog, KLF4 and Bmi-1 in ALDH/PI CSCs were upregulated compared with ALDH CSCs. (B) As assessed by a serial sphere forming assay, ALDH/PI CSCs exhibited a higher capacity of self-renewal compared with ALDH CSCs. (C) As assessed by limiting dilution assay, the ALDH/PI subpopulation had higher fraction of CSCs than ALDH cells. All data are presented as the mean ± standard deviation of three independent experiments. *P<0.05 vs. ALDH. ALDH, aldehyde dehydrogenase; PI, propidium iodide; CSCs, cancer stem cells; Oct4, octamer-binding transcription factor; KLF4, kruppel-like factor 4.