Figure 5.
ALDH/PI CSCs exhibit higher tumorigenicity than ALDH CSCs in vitro and in vivo. (A) ALDH CSCs formed a significantly lower number of colonies than the ALDH/PI CSCs as assessed by a colony formation assay. (B) Mice transplanted with ALDH/PI CSCs formed tumors earlier and formed significantly larger tumors than mice transplanted with ALDH CSCs. All data are presented as the mean ± standard deviation of three independent experiments. *P<0.05 vs. ALDH. ALDH, aldehyde dehydrogenase; CSCs, cancer stem cells; PI, propidium iodide.