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. 2017 Jul 28;14(4):2801–2808. doi: 10.3892/etm.2017.4846

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Copyright: © Leng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — The co-expression of ALDH and EMT key regulators. (A) Laser confocal analysis confirming the presence of ALDH and the EMT key regulator vimentin in ALDH^high CSCs. Nuclei were stained with DAPI. Scale bar=25 µm; magnification, ×400. (B) Levels of E-cadherin mRNA were decreased in ALDH^high CSCs, whereas levels of the mesenchymal molecules vimentin, snail and slug were highly expressed in ALDH^high CSCs. All data are presented as the mean ± standard deviation of three independent experiments. *P<0.05 vs. ALDH. EMT, epithelial-mesenchymal transition; ALDH^high, high aldehyde dehydrogenase; CSCs, cancer stem cells; DAPI, 4′,6-diamidino-2-phenylindole.