Table I.
Differentially expressed proteins identified in PCA.
| Accession no. | Gene abbreviation | Gene name | Expression ratioa | P-value |
|---|---|---|---|---|
| 4557581 | FABP5 | Fatty acid-binding protein, epidermal | 2.990 | 6.05×10−10 |
| 1195531 | KRT16 | Type I keratin 16 | 2.757 | 1.61×10−6 |
| 189053201 | S100A9 | S100 calcium-binding protein A9 | 2.602 | 9.96×10−26 |
| 223278387 | CALML5 | Calmodulin-like protein 5 (calmodulin-like skin protein) | 2.598 | 3.50×10−4 |
| 21614544 | S100A8 | S100 calcium-binding protein A8 | 2.557 | 1.32×10−6 |
| 12053626 | S100A7 | Psoriasin (S100 calcium-binding protein A7) | 2.315 | 2.11×10−24 |
| 194387918 | KRT6A | Keratin, type II cytoskeletal 6A | 2.088 | 4.70×10−7 |
| 553348 | TNC | Hexabrachion | 1.992 | 1.51×10−5 |
| 457464 | DSC1 | Dsc1a precursor (desmocollin 1) | 1.983 | 4.18×10−3 |
| 124056490 | COL3A1 | Collagen α1 (III) chain | 1.845 | 3.57×10−61 |
| 6912286 | CASP14 | Caspase-14 precursor | 1.834 | 2.08×10−12 |
| 49660012 | TPM1 | Sarcomeric tropomyosin κ | 1.821 | 2.05×10−3 |
| 1942977 | MIF | Chain a, macrophage migration inhibitory factor | 1.816 | 4.84×10−7 |
| 4503113 | CST6 | Cystatin-M precursor | 1.809 | 1.39×10−2 |
| 110349772 | COL1A1 | Collagen α1 (I) chain preproprotein | 1.744 | 0.00×100 |
| 115527066 | COL6A2 | Collagen α2 (VI) chain isoform 2C2a precursor | 1.734 | 1.52×10−3 |
| 178849 | APOE | Apolipoprotein E | 1.720 | 2.47×10−7 |
| 119585301 | COL7A1 | Collagen, type VII, α1 (epidermolysis bullosa, dystrophic, dominant and recessive), isoform CRA_e | 1.703 | 1.26×10−3 |
| 4505047 | LUM | Lumican precursor | 1.700 | 7.83×10−168 |
| 453157 | FMOD | Fibromodulin | 1.689 | 1.68×10−2 |
| 48255905 | TAGLN | Transgelin (SM22) | 1.683 | 1.10×10−18 |
| 183583553 | COL4A5 | Collagen α5 (VI) chain | 1.681 | 2.29×10−2 |
| 21708099 | DPT | Dermatopontin | 1.647 | 6.17×10−12 |
| 32451581 | COL1A2 | Collagen, type I, α2 | 1.640 | 1.03×10−138 |
| 4885165 | CSTA | Cystatin-A | 1.567 | 1.61×10−2 |
| 166343769 | gi|166343769 | Periostin isoform thy6 | 1.557 | 5.03×10−20 |
| 49456765 | SFN | Stratifin | 1.519 | 1.12×10−20 |
| 113414871 | KRT77 | Keratin 77 (type II) | 0.664 | 2.24×10−2 |
| 126035028 | HIST1H1E | Liver histone H1e | 0.646 | 2.35×10−4 |
| 119573007 | APOA2 | Apolipoprotein A-II, isoform CRA_d | 0.644 | 4.99×10−13 |
| 221045918 | TUBB4B | Tubulin β-4B chain | 0.643 | 1.77×10−5 |
| 167614485 | ACAA2 | 3-ketoacyl-coa thiolase, mitochondrial | 0.642 | 5.18×10−5 |
| 9857759 | gi|9857759 | Recombinant IgG4 heavy chain | 0.633 | 1.53×10−50 |
| 193785892 | ATP2A1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 0.631 | 1.55×10−3 |
| 4502011 | AK1 | Adenylate kinase isoenzyme 1 | 0.620 | 2.98×10−3 |
| 221041416 | ACSL1 | Long-chain-fatty-acid-coA ligase 1 | 0.619 | 2.69×10−3 |
| 297304885 | FHL1 | PREDICTED: Four and a half LIM domains protein 1 | 0.613 | 3.48×10−3 |
| 194387956 | ADH1B | Alcohol dehydrogenase 1B | 0.593 | 6.27×10−17 |
| 61743954 | AHNAK | Neuroblast differentiation-associated protein AHNAK isoform 1 | 0.587 | 5.05×10−126 |
| 109731497 | MYH1 | Myosin, heavy chain 1, skeletal muscle, adult | 0.573 | 3.85×10−5 |
| 4506335 | PVALB | Parvalbumin α | 0.518 | 3.43×10−2 |
| 194374151 | ENO3 | β-enolase; 2-phospho-D-glycerate hydro-lyase | 0.504 | 9.95×10−4 |
| 34071 | KRT15 | Keratin 15 (type I) | 0.501 | 2.98×10−16 |
| 153791586 | MYH2 | Myosin-2 | 0.492 | 1.16×10−28 |
| 109111058 | TPM2 | PREDICTED: β-tropomyosin isoform | 0.445 | 1.22×10−2 |
| 825683 | TMSB4X | Thymosin β4 | 0.427 | 1.05×10−2 |
| 4507617 | TNNC2 | Troponin C, skeletal muscle | 0.421 | 3.93×10−7 |
| 28372499 | MYL2 | Myosin regulatory light chain 2, skeletal muscle isoform | 0.412 | 5.07×10−16 |
| 168985192 | MB | Myoglobin | 0.356 | 8.45×10−6 |
| 189053833 | CKM | Creatine kinase, muscle (CKM) | 0.354 | 1.04×10−11 |
| 17986273 | MYL1 | Myosin light chain 1/3, skeletal Muscle isoform isoform 1f | 0.304 | 2.95×10−15 |
a
Protein ratio of the PCA group vs. the control group. PCA, primary cutaneous amyloidosis.