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. 2017 Sep 1;8:113. doi: 10.3389/fgene.2017.00113

Figure 3.

Figure 3

Lifespan of S6K1 conditional KO strains in the Ndufs4 −/− background. (A) Lifespan of homozygous S6K1 flox-out (whole body S6K1 KO, n = 20, 6 female and 14 male) and their littermate heterozygous S6K1 flox-out (n = 21, 12 female and 9 male) by CMV-cre. P < 0.05. (B) Lifespan of Albumin-cre; S6K1fl/fl; Ndufs4−/− (Liver S6K1 cKO, n = 21, 9 female and 12 male) and their littermates without the cre gene (n = 20, 10 female and 10 male). p < 0.05. (C) Lifespan of Adiponectin-cre; S6K1fl/fl; Ndufs4−/− (Fat S6K1 cKO, n = 21, 15 female and 6 male) and their littermates without the cre gene (n = 21, 8 female and 13 male). (D) Lifespan of Synapsin1-cre; S6K1fl/fl; Ndufs4−/− (Brain S6K1 cKO, n = 12, 5 female and 7 male) and their littermates without the cre gene (n = 18, 11 female and 7 male).