Table 1.

Atomic structures of PrP steric zippers

Residues	Sequence	Zipper classa	Mutation	Species	PDB ID	Reference
113–118	AGAAAA	7		Human		M Apostol, HT McFarlane, DS Eisenberg, et al., unpubl.
119–124	GAVVGG	4		Human		M Apostol, HT McFarlane, DS Eisenberg, et al., unpubl.
126–131	GGYMLG	7		Human	4tut	Yu et al. 2015
127–132	GYMLGS	8		Human	3nhc	Apostol et al. 2010
126–131	GGYVLG	8	M129V	Human	4uby	Yu et al. 2015
127–132	GYVLGS	8	M129V	Human	3nhd	Apostol et al. 2010
138–143	MMHFGN	6		Hamster	3nve	Apostol et al. 2011
138–143	IIHFGS	1		Human	3nvf	Apostol et al. 2011
138–143	MIHFGN	1		Mouse	3nvg	Apostol et al. 2011
170–175	NNQNTF	1		Elk	3fva	Wiltzius et al. 2009
170–175	SNQNNF	2		Human	2ol9	Sawaya et al. 2007

All numbers correspond to the human sequence.

PDB, Protein Data Bank.

^aZipper classes are defined in Sawaya et al. 2007.