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Drosophila embryo patterning. Wider distribution of pMad (early blastoderm) is converted to a restricted pMad stripe (late blastoderm) through the action of Sog, Tsg, and Tld. The combined activities of these factors result in net flux of the Dpp–Scw heterodimer to the dorsal midline. Homodimers stay broadly distributed as a result of low affinity to Sog.
