Table 2.

Results from combined ancestry ExWAS meta-analysis

rsID	Chr	Gene(s)	Location relative to gene	Risk allele/reference allele	Risk allele frequency, %	OR	95% CI	P-value
Novel associations
rs6800541	3p22	SCN10A	Intronic	T/C	61	1.08	1.05–1.12	8.79×10−7
rs89107	6q22	SLC35F1/PLN	Intronic	G/A	58	1.07	1.04–1.10	9.51×10−7
rs11047543	12p12	SOX5	Intergenic	G/A	86	1.14	1.10–1.19	2.47×10−12
Previously known associations
rs13376333	1q21	KCNN3	Intronic	T/C	23	1.13	1.09–1.16	1.46×10−12
rs17042171	4q25	PITX2	Intergenic	A/C	21	1.64	1.59–1.69	8.31×10−227
rs3807989	7q31	CAV1	Intronic	G/A	58	1.09	1.06–1.12	6.52×10−8
rs60632610	10q22	SYNPO2L	Exonic; nonsyn	C/T	85	1.12	1.08–1.15	1.54×10−10
rs10151658	14q23	SYNE2	Exonic; nonsyn	C/A	49	1.07	1.04–1.09	5.16×10−7
rs2106261	16q22	ZFHX3	Intronic	A/G	17	1.21	1.16–1.26	4.00×10−19

The most significant variant at each genetic locus associated with atrial fibrillation is listed. Gene names in bold font indicate that the variant is located within the gene, whereas additional gene names indicate eQTL gene or gene strongly suspected to be causal due to the function of the encoded protein. For intergenic variants, the closest gene(s) are listed. Chr, chromosome; CI, confidence interval; OR, odds ratio; nonsyn, nonsynonymous.