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. Author manuscript; available in PMC: 2017 Sep 6.
Published in final edited form as: Mol Pharm. 2015 Feb 6;12(3):783–793. doi: 10.1021/mp5006118

Figure 8.

Figure 8

EDC reactions with gelatin after formation of the O-acylisourea intermediate. (1) reaction with water, (2) slow reaction with amino groups, (3) reaction with a nearby carboxyl group, (4) formation of N-acylisourea, and (5) fast reaction of anhydride with amino group (after Nakajima and Ikada6).