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. 2017 Sep 6;18:387. doi: 10.1186/s12891-017-1743-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Forest plots of cartilage structure synthesis and degradation in vitro: (a) ACAN and COL2A1 anabolic gene expression in chondrocytes or cartilage explants, comparing HA + AI and HA; (b) ADAMTS5, COX-2, IL-1β, MMP2, MMP3, and MMP13 catabolic gene expression in chondrocytes or cartilage explants, comparing HA + AI and HA; (c) GAG remaining in chondrocyte pellets or cartilage explants, comparing HA + AI and HA. ACAN, aggrecan gene; AI, anti-inflammatory drugs; CI, confidence interval; COL2A1, collagen type II alpha 1 gene; GAG, glycosaminoglycans; HA, hyaluronic acid; RE, random effects model