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. 2017 Sep 6;5:66. doi: 10.1186/s40478-017-0464-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Intrathecal administration of AAV9-CAG-hGAA improves cardiac hypertrophy and both serotypes increase the gene expression of cardiac structural proteins. a Left ventricular free wall thickness measurement at the end of diastole by echocardiography M-mode (one-way ANOVA with Newman-Keuls post hoc test; n = 8 to 10 per group: **P < 0.01, ***P < 0.001). b Heart to body weight ratio at euthanasia (one-way ANOVA with Newman-Keuls post hoc test; n = 8 to 13 per group: *P < 0.05, ***P < 0.001). c Cardiac structural proteins transcript quantification, mRNA up- or down-regulation relative to WT levels (n = 4 per group). Myosin beta heavy chain 7 of cardiac muscle (myh7), actin alpha cardiac muscle 1 (actc1), and actin alpha 1 (acta1). (one-way ANOVA with Newman-Keuls post hoc test; n = 8 to 13 per group: *P < 0.05, **P < 0.01)