Table 4.
Transcription profile of selected C. albicans effectors genes upon neutrophil challenge
C. albicans yeast [log2] | C. albicans hyphae [log2] | |||||||
---|---|---|---|---|---|---|---|---|
15 min | 30 min | 60 min | NETs | 15 min | 30 min | 60 min | NETs | |
SOD1 | −0.38 | −0.02 | −1.39 | −0.41 | 1.15 | 0.72 | 0.24 | 0.94 |
SOD2 | −0.60 | −0.61 | −0.62 | 0.12 | −0.40 | −0.66 | −0.48 | 0.63 |
SOD3 | 1.75 | −0.68 | 2.98 | 0.55 | −0.24 | 0.30 | 1.19 | 1.04 |
SOD4 | 1.18 | 2.24 | 2.53 | 0.57 | 0.65 | 1.26 | 1.49 | 0.31 |
SOD5 | 1.45 | 0.90 | 0.43 | 1.64 | 0.91 | 0.83 | 0.56 | 0.15 |
SOD6 | 1.45 | 0.90 | 0.43 | 1.64 | 0.84 | 0.42 | 0.41 | 1.31 |
CAT1 | 0.67 | −0.08 | −1.08 | 1.33 | 1.00 | −0.04 | −0.87 | 1.20 |
TRX1 | 0.45 | 0.06 | −0.97 | 0.56 | 1.19 | 0.61 | 0.28 | 0.83 |
ECE1 | 3.81 | 6.63 | 9.22 | 1.15 | −1.16 | −1.06 | −1.48 | −0.22 |
PRA1 | 3.32 | 1.03 | 1.49 | 1.77 | −0.27 | 0.35 | 0.63 | 0.90 |
ALS3 | 1.56 | 3.05 | 4.52 | −0.37 | −1.13 | −1.25 | −1.62 | −0.52 |
Neutrophils | Neutrophils |
The transcript pattern of typical C. albicans effector genes affected during neutrophil encounter and NETs challenge is displayed by fold change. The transcript levels during neutrophil infection were corrected by the transcript levels in the same environment without neutrophils (medium, temperature) at every given time point