Table 3.
The top ten most overrepresented Biological Functions in each species, determined using g:Cocoa
| Function | GO Term | No. genes in term | No. genes overexpressed in woodrats | No. genes overexpressed in lab rats |
|---|---|---|---|---|
| Overrepresented in woodrats | ||||
| Cellular component organization | GO:0016043 | 5139 | 347 | 252 |
| Metabolic process | GO:0008152 | 11,355 | 638 | 580 |
| Actin cytoskeleton organization | GO:0030036 | 520 | 65 | 18 |
| Intracellular signal transduction | GO:0035556 | 2241 | 176 | 1 |
| Cellular component morphogenesis | GO:0032989 | 1204 | 112 | 29 |
| Regulation of multicellular organismal process | GO:0051239 | 2423 | 175 | 62 |
| Regulation of molecular function | GO:0065009 | 2460 | 174 | 61 |
| Regulation of intracellular signal transduction | GO:1,902,531 | 1417 | 107 | 1 |
| Cell migration | GO:0016477 | 1081 | 53 | 55 |
| Muscle contraction | GO:0006936 | 240 | 25 | 3 |
| Overrepresented in lab rats | ||||
| Single-organism metabolic process | GO:0044710 | 4526 | 265 | 305 |
| Immune response | GO:0006955 | 1107 | 10 | 69 |
| Defense response | GO:0006952 | 1264 | 20 | 65 |
| Organic hydroxy compound metabolic process | GO:1,901,615 | 431 | 22 | 43 |
| Positive regulation of cell activation | GO:0050867 | 250 | 8 | 21 |
| Positive regulation of T cell activation | GO:0050870 | 155 | 5 | 16 |
| Neutrophil migration | GO:1,990,266 | 94 | 1 | 11 |
| Nuclear DNA replication | GO:0033260 | 15 | 1 | 6 |
| L-serine biosynthetic process | GO:0006564 | 4 | 0 | 4 |
| Localization | GO:0051179 | 5203 | 289 | 305 |
Corrected p-values are all less than 0.001. We used the moderate filtering to first identify the most differentially represented term per parent group