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. 2017 Sep 5;18:166. doi: 10.1186/s13059-017-1301-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Modest activation of ISG expression in Adar1 ^E861A/E861A Ifih1 ^-/- tissues. a Quantitative reverse transcription polymerase chain reaction (qRT-PCR) of four ISGs from tissues of 12-week-old mice, with the exception of the first panel comparing 12-week-old brain with E12.5 fetal brain from Adar1 ^E861A/E861A Ifih1 ^+/+ embryos. Data represent mean ± SEM (n = 3/genotype); all samples normalized to C57BL/6. b PB serum cytokine levels from indicated genotypes. Positive control = supernatant from tamoxifen treated R26-CreER^T2 Adar1 ^E861A/fl hematopoietic cell line. Results are mean ± SEM; significance determined using two-way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001