Table 2.
Predictors of Baseline Advanced Fibrosis (LSM >7.6 kPa) by Univariate and Multivariable Logistic Regression
| Advanced Fibrosis (N=28) | No Advanced Fibrosis (N=67) | Univariate Analysis | Multivariable Analysisa | ||||
|---|---|---|---|---|---|---|---|
| Characteristic | Data Totalb | N (%) or Median (IQR) | ORc (95% CI) | p-value | ORc (95% CI) | p-value | |
| Age, years | 95 | 41 (29.5–44.5) | 32 (28–26) | 1.06 (1.01–1.11) | 0.011 | 1.18 (0.95–1.74) | 0.126 |
| Female | 95 | 13 (46.4%) | 43 (64.2%) | 0.46 (0.19–1.14) | 0.094 | – | – |
| BMI, kg/m2 | 95 | 22.5 (20.3–24.6) | 23.6 (20–26.7) | 0.96 (0.87–1.05) | 0.336 | ||
| EtOH Use, yes | 95 | 13 (46.4%) | 12 (17.9%) | 3.90 (1.48–10.3) | 0.006 | – | – |
| CD4 < 200 cells/mm3 | 95 | 9 (32.1%) | 19 (28.4%) | 1.26 (0.43–3.3) | 0.634 | ||
| Log10 HIV RNA, copies/ml | 95 | 4.6 (4.1–5.3) | 4.8 (4.3–5.4) | 0.88 (0.49–1.59) | 0.674 | ||
| Log10 HBV DNA, IU/ml | 95 | 4.4 (0–6.7) | 0 (0–2.8) | 1.24 (1.06–1.44) | 0.006 | – | – |
| HBeAgd Reactive | 93 | 9 (33.3%) | 10 (15.2%) | 2.75 (0.97–7.83) | 0.058 | – | – |
| BCP A1762T/G1764G | 35 | 6 (50%) | 10 (62.5%) | 1.3 (0.32–5.27) | 0.713 | ||
| BCP C1766G | 35 | 3 (35%) | 3 (13%) | 2.22 (0.37–13.2) | 0.292 | ||
| PC G1896A | 35 | 7 (58.3%) | 13 (56.5%) | 1.17 (0.28–4.91) | 0.380 | ||
| A1762T/G1764A + G1896A | 35 | 3 (35%) | 4 (17.4%) | 1.58 (0.29–8.62) | 0.595 | ||
| PreS2 InDels | 16 | 6 (66.7%) | 1 (14.3%) | 20 (1.68–238) | 0.036 | 37 (1.01–1312) | 0.047 |
| S I110L | 45 | 2 (14.3%) | 3 (9.7%) | 1.56 (0.23–10.53) | 0.651 | ||
| S E164G/A | 45 | 1 (7.1%) | 5 (16.1%) | 0.40 (0.04–3.79) | 0.424 | ||
| ‘A’ Determinant Mutations | 45 | 3 (21.4%) | 9 (29%) | 0.67 (0.15–2.97) | 0.595 | ||
Abbreviations: LSM, liver stiffness measurement; kPa, kilopascal; BMI, body-mass-index; EtOH, alcohol; CD4+, CD4+ T-cell count; HIV, human immunodeficiency virus; HBV, hepatitis B virus; BCP, basal core promoter; PC, precore; indel, insertion-deletion mutant
The multivariate model assessed covariates with p<0.20 in univariate model via backward stepwise regression – in MV column indicates covariates that were assessed and removed from final model due to non-significance
Total number of patients with valid data for each variable. Values < 95 are representative of missing data, or insufficient sample / inability to sequence the patient sample
For all continuous variables, ORs are measured per unit increment
Includes 5 patients with concurrent HBeAg and anti-HBe