Table 3.
Grouping of cerebral cortex tissue sections indicates distinct regional distribution and genetic heterogeneity
| Measure | Estimate | Standard error | Chi-squared with DF = 1 (P-Value) | OR (95% CI) | Chi-squared (DF) (P-Value) |
|---|---|---|---|---|---|
| Phase | |||||
| Ia | −1.112 | 0.307 | 13.10 (0.0003) | 0.33 (0.18-0.60) | 15.72 (2) (0.0004) |
| IIb | −0.180 | 0.344 | 0.27 (0.6005) | 0.84(0.43-1.64) | |
| III/IVc | 1.292 | 0.270 | 22.84 (<0.0001) | 3.64 (2.14-6.18) | |
| Mutation | |||||
| Non-C9/GRNd | 1.038 | 0.448 | 5.37 (0.0205) | 2.82 (1.17-6.80) | 7.80 (2) (0.0203) |
| C9orf72 e | −0.996 | 0.390 | 6.52 (0.0107) | 0.37 (0.17-0.79) | |
| GRN f | −0.043 | 0.465 | 0.01 (0.9269) | 0.95 (0.39-2.38) | |
aPhase III/IV is reference group
bI is reference group
cII is reference group
d GRN is reference group
eNon-C9/GRN is reference group
f C9orf72 is the reference group
GEE using a proportional odds model for Group 1-2 based on 273 observations. I- orbital frontal cortex; II- mid-frontal, anterior cingulate, entorhinal and superior temporal cortices; III- motor, sensory, and angular cortices; IV- visual cortex. Regions in III and IV are combined due to small number of observations in each region