Table 1.
Size and ζ-potential of F127 and F68-coated NS formulations and uncoated PS-COOH nanoparticles with ratios of their ensemble average MSD in human CVM (<MSD>m) compared to the theoretical diffusion rates in water (MSDw).
| NS/Particle Type | Mean Diameter [nm]a | ζ-Potential [mV]a | MSDw/<MSD>mb | |
|---|---|---|---|---|
| in CVM | in CFS | |||
| CUR-F127 | 133 ± 12 | − 0.8 ± 0.1 | 9 | 37 |
| CUR-0.1%F127 | 154 ± 4 | − 1.4 ± 0.4 | 11 | – |
| CUR-0.01%F127 | 176 ± 11 | − 1.6 ± 0.3 | 35 | – |
| CUR-0.001%F127 | 184 ± 30 | − 1.3 ± 0.5 | 10,000 | – |
| CUR-F68 | 154 ± 20 | − 1.4 ± 0.1 | 150 | – |
| p-THPP-F127 | 323 ± 8 | 0.3 ± 0.4 | 5 | – |
| PS-COOH | 210 ± 15 | − 50 ± 4 | 25,000 | 5,200 |
a
Mean diameter and ζ-potential were measured via dynamic light scattering and laser Doppler electrophoresis, respectively. Data represent mean ± standard error (n ≥ 3).
b
MSDw is calculated from the Stokes-Einstein equation based on average particle diameter and at the time scale of 1s. <MSD>m is the geometric ensemble average of MSD at a time scale of 1s.