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. Author manuscript; available in PMC: 2017 Sep 6.
Published in final edited form as: Dev Biol. 2017 Jul 14;429(1):105–117. doi: 10.1016/j.ydbio.2017.07.002

Fig. 2. N-myc inactivation in the lens impair eye and lens growth.

Fig. 2

(A-C) Measurements of lens volume (adult) and eye volume (P0 and adult) in N-mycCtrl (n = 9), N-mycMlr10-Cre (n = 5), N-mycLe-Cre (n = 6) (control = 100%). (D) Visual acuity by optomotor response test in adult (P60) N-mycCtrl (n = 12) and N-mycMlr10-Cre (n = 13) mice. (E-F) Representative pictures of haematoxilin & eosin stainings of E12.5 and E17.5 lenses. (G-H) Representative pictures of DAPI nuclear staining of E17.5 and P7 lenses. (g′) Insets from (G) reveal the absence or presence of nuclei in the center of the E17.5 control and N-myc-deficient lenses. (I) Representative pictures of isolated lenses from P60 mice. One-way ANOVA with Tukey's posttest performed in A-C and a t-test in D. Error bars indicate S.D.; **p < 0.01, *** p < 0.001, ****p < 0.0001. Scale bar: 100 µm.