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. Author manuscript; available in PMC: 2017 Sep 6.
Published in final edited form as: ACS Nano. 2014 Feb 25;8(3):2087–2099. doi: 10.1021/nn500376w

Figure 10.

Figure 10

MWCNT-COOH affects IGF-1 functions. Shattered plots of mRNA level of HEK 293 cells treated with MWCNT-COOH (A) or MWCNT 41 (B). (C) Bar chart of relative mRNA level of IGF1. (D) Immunoblot assay indicated that MWCNT-COOH, but not MWCNT 41, inhibits IGF-1 protein level. And MWCNT 41 inhibited IFNA2 more significantly than MWCNT-COOH. The gray intensity of the bands was quantified against GAPDH by ImageJ and labeled above each bands. (E) Current understanding of MWCNT-COOH induced autophagy. MWCNT-COOH induced mTOR dependent autophagy through blockade of IGF-1 expression. Green arrow means induction, red line means suppression, while dashed line indicates a pathway that needs further investigation.