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(a–l) Force on the harmonic spring at the pulling end was measured every picometer in independent simulations at the indicated pulling rates. The four major events in straitjacket removal are arrowed in each simulation with two-letter codes. The first letter is F for fastener unsnapping and A for α2 helix unfolding. The second letter is I for the integrin-bound monomer and N for the non-bound monomer.
